Polymer Networks Combining Controlled Drug Release, Biodegradation, and Shape Memory Capability

Authors

  • Axel T. Neffe,

    1. Center for Biomaterial Development, Institute of Polymer Research GKSS Research Centre Geesthacht GmbH Kantstrasse 55, 14513 Teltow (Germany)
    2. Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Charité-Universitätsmedizin Berlin-BCRT, Campus Virchow-Klinikum Augustenburger Platz 1, 13353 Berlin (Germany)
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  • Bui D. Hanh,

    1. Center for Biomaterial Development, Institute of Polymer Research GKSS Research Centre Geesthacht GmbH Kantstrasse 55, 14513 Teltow (Germany)
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  • Susi Steuer,

    1. Center for Biomaterial Development, Institute of Polymer Research GKSS Research Centre Geesthacht GmbH Kantstrasse 55, 14513 Teltow (Germany)
    2. Present address: Intervet Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany
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  • Andreas Lendlein

    Corresponding author
    1. Center for Biomaterial Development, Institute of Polymer Research GKSS Research Centre Geesthacht GmbH Kantstrasse 55, 14513 Teltow (Germany)
    2. Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Charité-Universitätsmedizin Berlin-BCRT, Campus Virchow-Klinikum Augustenburger Platz 1, 13353 Berlin (Germany)
    • Center for Biomaterial Development, Institute of Polymer Research GKSS Research Centre Geesthacht GmbH Kantstrasse 55, 14513 Teltow (Germany).
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Abstract

original image

A triple functional polymer network system that combines shape-memory capability, biodegradability, and drug release is developed. The choice of network structure and switching segment prevent that drug incorporation substantially changes the thermal and mechanical properties as well as the shape-memory functionality (see recovery curves). A diffusion-controlled release that is independent from biodegradation is enabled.

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