Communication

Encoded Porous Beads for Label-Free Multiplex Detection of Tumor Markers

  1. Yuanjin Zhao1,
  2. Xiangwei Zhao1,
  3. Jing Hu1,
  4. Ming Xu1,
  5. Wenju Zhao1,
  6. Liguo Sun1,
  7. Cun Zhu1,
  8. Hua Xu1,
  9. Zhongze Gu1,2,*

Article first published online: 18 NOV 2008

DOI: 10.1002/adma.200802339

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 5, pages 569–572, February 2, 2009

Additional Information

How to Cite

Zhao, Y., Zhao, X., Hu, J., Xu, M., Zhao, W., Sun, L., Zhu, C., Xu, H. and Gu, Z. (2009), Encoded Porous Beads for Label-Free Multiplex Detection of Tumor Markers. Advanced Materials, 21: 569–572. doi: 10.1002/adma.200802339

Author Information

  1. 1

    State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 (P.R. China)

  2. 2

    Laboratory of Environment and Biosafety Research Institute of Southeast University in Suzhou Suzhou 215123(P.R. China)

*State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 (P.R. China).

Publication History

  1. Issue published online: 22 JAN 2009
  2. Article first published online: 18 NOV 2008
  3. Manuscript Received: 12 AUG 2008

Funded by

  • Ministry of Science and Technology. Grant Number: 2006AA03Z331
  • National Science Foundation of China. Grant Numbers: 20573018, 60121101, 20703010
  • Jiangsu Natural Science Foundation. Grant Number: BK2008318

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Keywords:

  • Opals;
  • Inverse opaline photonic bead;
  • Label-free assay;
  • Suspension array;
  • Tumor marker

Graphical Abstract

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Inverse-opaline photonic beads are used as the elements of a suspension array for label-free multiplex immunoassays. As in the case of tumor-marker detection, specific binding of tumor markers on the pore surfaces of the beads results in a shift in the diffraction-peak position, which can be used for quantitatively estimating the amount of bound tumor marker.

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