Antimicrobial Nanotubes Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes as Delivery Vehicles

Authors

  • Yong Zhou,

    1. SORST, Japan Science and Technology Agency (JST) Tsukuba Central 5, 1-1-1 Higashi Tsukuba Ibaraki 305-8565 (Japan)
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  • Masaki Kogiso,

    1. SORST, Japan Science and Technology Agency (JST) Tsukuba Central 5, 1-1-1 Higashi Tsukuba Ibaraki 305-8565 (Japan)
    2. Nanotube Research Center (NTRC) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5, 1-1-1 Higashi, Tsukuba Ibaraki 305-8565 (Japan)
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  • Masumi Asakawa,

    1. SORST, Japan Science and Technology Agency (JST) Tsukuba Central 5, 1-1-1 Higashi Tsukuba Ibaraki 305-8565 (Japan)
    2. Nanotube Research Center (NTRC) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5, 1-1-1 Higashi, Tsukuba Ibaraki 305-8565 (Japan)
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  • Sijun Dong,

    1. Signaling Molecules Research Laboratory National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 6, 1-1-1 Higashi, Tsukuba Ibaraki 305-8566 (Japan)
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  • Ryoiti Kiyama,

    1. Signaling Molecules Research Laboratory National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 6, 1-1-1 Higashi, Tsukuba Ibaraki 305-8566 (Japan)
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  • Toshimi Shimizu

    Corresponding author
    1. SORST, Japan Science and Technology Agency (JST) Tsukuba Central 5, 1-1-1 Higashi Tsukuba Ibaraki 305-8565 (Japan)
    2. Nanotube Research Center (NTRC) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 5, 1-1-1 Higashi, Tsukuba Ibaraki 305-8565 (Japan)
    • SORST, Japan Science and Technology Agency (JST) Tsukuba Central 5, 1-1-1 Higashi Tsukuba Ibaraki 305-8565 (Japan).
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Abstract

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Functional drug-delivery vehicles consisting of Ag-embedded bilayer membranes of a peptidic lipid nanotube (LNT) are synthesized. The Ag–LNTs possess antimicrobial ability against E coli, contributing to the release of Ag+ into the aqueous culture. The Ag–LNTs may be applicable to the delivery of DNA or biotechnological drugs that are usually sensitive to changes in their surroundings.

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