Advanced Materials

Fluorescent Polystyrene–Fe3O4 Composite Nanospheres for In Vivo Imaging and Hyperthermia

Authors

  • Donglu Shi,

    Corresponding author
    1. The Institute for Advanced Materials and NanoBiomedicine Tongji University Shanghai 200092 (PR China)
    2. Department of Chemical and Materials Engineering, University of Cincinnati 493 Rhodes Hall, Cincinnati, OH 45221-0012 (USA)
    3. Institute for Micro-Nanoscience and technology Shanghai Jiao Tong University Shanghai 200240 (PR China)
    • Department of Chemical and Materials Engineering, University of Cincinnati 493 Rhodes Hall, Cincinnati, OH 45221-0012 (USA).
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  • Hoon Sung Cho,

    1. Department of Chemical and Materials Engineering, University of Cincinnati 493 Rhodes Hall, Cincinnati, OH 45221-0012 (USA)
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  • Yan Chen,

    1. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences Shanghai Institute for Biological Sciences, Chinese Academy of Sciences Shanghai 200031 (PR China)
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  • Hong Xu,

    1. Med - X Institute, Shanghai Jiao Tong University Shanghai 200030 (PR China)
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  • Hongchen Gu,

    1. Med - X Institute, Shanghai Jiao Tong University Shanghai 200030 (PR China)
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  • Jie Lian,

    1. Department of Mechanical, Aerospace & Nuclear Engineering Rensselaer Polytechnic Institute Jonsson Engineering Center Troy, NY12180 (USA)
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  • Wei Wang,

    1. Department of Chemical and Materials Engineering, University of Cincinnati 493 Rhodes Hall, Cincinnati, OH 45221-0012 (USA)
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  • Guokui Liu,

    1. Chemistry Division, Argonne National Laboratory Argonne, IL 60439 (USA)
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  • Christopher Huth,

    1. Department of Chemical and Materials Engineering, University of Cincinnati 493 Rhodes Hall, Cincinnati, OH 45221-0012 (USA)
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  • Lumin Wang,

    1. Departments of Geological Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering University of Michigan Ann Arbor, MI 48109 (USA)
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  • Rodney C. Ewing,

    1. Departments of Geological Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering University of Michigan Ann Arbor, MI 48109 (USA)
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  • Sergei Budko,

    1. Ames Laboratory and Department of Physics and Astronomy Iowa State University Ames, IA 50011 (USA)
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  • Giovanni M. Pauletti,

    1. James L. Winkle College of Pharmacy, University of Cincinnati Cincinnati, OH 45267 (USA)
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  • Zhongyun Dong

    1. Department of Internal Medicine, College of Medicine, University of Cincinnati Cincinnati, OH 45221 (USA)
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Abstract

Quantum dots (QDs) are immobilized on the surfaces of magnetic Fe3O4-composite nanospheres (MNSs, see figure). The QDs exhibit intense visible-light emission in fluorescence spectroscopy and successfully facilitate, for the first time, in vivo soft-tissue imaging in live mice. The Fe3O4 nanoparticles respond to an external magnetic field by increasing the temperature of the surrounding environment (i.e., hyperthermia), which can be used therapeutically.

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