Communication

SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating

  1. Geoffrey von Maltzahn1,
  2. Andrea Centrone3,
  3. Ji-Ho Park4,
  4. Renuka Ramanathan1,
  5. Michael J. Sailor4,5,
  6. T. Alan Hatton3,
  7. Sangeeta N. Bhatia1,2,*

Article first published online: 20 APR 2009

DOI: 10.1002/adma.200803464

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 31, pages 3175–3180, August 21, 2009

Additional Information

How to Cite

von Maltzahn, G., Centrone, A., Park, J.-H., Ramanathan, R., Sailor, M. J., Hatton, T. A. and Bhatia, S. N. (2009), SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating. Adv. Mater., 21: 3175–3180. doi: 10.1002/adma.200803464

Author Information

  1. 1

    Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  2. 2

    Electrical Engineering and Computer Science, MIT David H. Koch Institute for Integrative Cancer Research Department of Medicine, Brigham and Women's Hospital, and Howard Hughes Medical Institute Boston, MA (USA)

  3. 3

    Department of Chemical Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  4. 4

    Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)

  5. 5

    Departments of Bioengineering and Nanoengineering University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)

*Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).

Publication History

  1. Issue published online: 17 AUG 2009
  2. Article first published online: 20 APR 2009
  3. Manuscript Revised: 20 FEB 2009
  4. Manuscript Received: 25 NOV 2008

Funded by

  • National Cancer Institute of the National Institutes of Health. Grant Numbers: N01-C0-37117, R01CA124427-01, UO1 HL 080718
  • NIH Grant. Grant Number: U54 CA 119335
  • NSF
  • Whitaker Graduate Fellowships

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Keywords:

  • cancer;
  • multiplexing;
  • nanorods;
  • nanotechnology;
  • SERRS;
  • SERS
Thumbnail image of graphical abstract

Screening nanorods coated with a mixture of SERS active molecules and biocompatible polymer identifies three formulations that may be uniquely distinguished in vivo over a spectral bandwidth of only 6 nm in the near-infrared (a spectral multiplexing density over an order of magnitude greater than attainable with semiconductor quantum dots, organic fluorochromes, and Raleigh scattering nanoparticle imaging approaches), while providing intense photothermal heating for cancer therapy.

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