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SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating

Authors

  • Geoffrey von Maltzahn,

    1. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Andrea Centrone,

    1. Department of Chemical Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Ji-Ho Park,

    1. Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
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  • Renuka Ramanathan,

    1. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Michael J. Sailor,

    1. Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
    2. Departments of Bioengineering and Nanoengineering University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
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  • T. Alan Hatton,

    1. Department of Chemical Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Sangeeta N. Bhatia

    Corresponding author
    1. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
    2. Electrical Engineering and Computer Science, MIT David H. Koch Institute for Integrative Cancer Research Department of Medicine, Brigham and Women's Hospital, and Howard Hughes Medical Institute Boston, MA (USA)
    • Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).
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Abstract

original image

Screening nanorods coated with a mixture of SERS active molecules and biocompatible polymer identifies three formulations that may be uniquely distinguished in vivo over a spectral bandwidth of only 6 nm in the near-infrared (a spectral multiplexing density over an order of magnitude greater than attainable with semiconductor quantum dots, organic fluorochromes, and Raleigh scattering nanoparticle imaging approaches), while providing intense photothermal heating for cancer therapy.

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