Cover Picture: Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging (Adv. Mater. 9/2008)

Authors

  • Ji-Ho Park,

    1. Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
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  • Geoffrey von Maltzahn,

    1. Harvard–MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Lianglin Zhang,

    1. Burnham Institute for Medical Research at UCSB University of California, Santa Barbara 1105 Life Sciences Technology Bldg., Santa Barbara, CA 93106 (USA)
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  • Michael P. Schwartz,

    1. Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
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  • Erkki Ruoslahti,

    1. Burnham Institute for Medical Research at UCSB University of California, Santa Barbara 1105 Life Sciences Technology Bldg., Santa Barbara, CA 93106 (USA)
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  • Sangeeta N. Bhatia,

    1. Harvard–MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)
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  • Michael J. Sailor

    Corresponding author
    1. Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)
    • Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA).
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Abstract

original image

The synthesis and biological behavior of tumor-homing magnetic iron oxide nanoworms consisting of a chain-like aggregation of iron oxide nanoparticle cores in a dextran coating are reported by Michael J. Sailor and co-workers on p. 1630. The elongated particles display an enhanced magnetic resonance response and long in vivo circulation times. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles.

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