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Bionanocomposites as New Carriers for Influenza Vaccines

Authors

  • Eduardo Ruiz-Hitzky,

    Corresponding author
    1. Instituto de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Inés de la Cruz 3, 28049 Madrid (Spain)
    • Instituto de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Inés de la Cruz 3, 28049 Madrid (Spain).
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  • Margarita Darder,

    1. Instituto de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Inés de la Cruz 3, 28049 Madrid (Spain)
    2. Instituto Madrileño de Estudios Avanzados en Materiales (IMDEA-Materiales) C/ Profesor Aranguren s/n, 28040 Madrid (Spain)
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  • Pilar Aranda,

    1. Instituto de Ciencia de Materiales de Madrid, CSIC C/ Sor Juana Inés de la Cruz 3, 28049 Madrid (Spain)
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  • M. Ángeles Martín del Burgo,

    1. Department of Biotechnology, INIA Ctra. de la Coruña Km 7,5, 28040 Madrid (Spain)
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  • Gustavo del Real

    1. Department of Biotechnology, INIA Ctra. de la Coruña Km 7,5, 28040 Madrid (Spain)
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Abstract

Bionanocomposites resulting from the assembly of negatively charged polysaccharides (xanthan gum) and sepiolite at the nanometer scale are able to associate efficiently to influenza-virus particles. This produces stable dispersions suitable as effective intranasal or intramuscular flu vaccines, as confirmed from experiments carried out in mice.

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