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Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

Authors

  • Shyam Karki,

    1. Department of Chemistry and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge Lensfield Road Cambridge, CB21EW (UK)
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  • Tomislav Friščić,

    1. Department of Chemistry and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge Lensfield Road Cambridge, CB21EW (UK)
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  • László Fábián,

    1. Cambridge Crystallographic Data Centre 12 Union Road, Cambridge CB21EZ (UK)
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  • Peter R. Laity,

    1. Department of Materials Science and Metallurgy and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge New Museums Site, Pembroke Street Cambridge CB23QZ (UK)
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  • Graeme M. Day,

    1. Department of Chemistry and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge Lensfield Road Cambridge, CB21EW (UK)
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  • William Jones

    Corresponding author
    1. Department of Chemistry and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge Lensfield Road Cambridge, CB21EW (UK)
    • Department of Chemistry and Pfizer Institute for Pharmaceutical Materials Science University of Cambridge Lensfield Road Cambridge, CB21EW (UK).
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Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

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