Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

Authors

  • Patricia M. Davidson,

    1. Institut de Science des Matériaux de Mulhouse CNRS LRC 7228 Université de Haute-Alsace 15, rue Jean Starcky, BP 2488 68057 Mulhouse Cedex (France)
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  • Hayriye Özçelik,

    1. METU, BIOMAT Department of Biological Sciences Biotechnology Research Unit 06531 Ankara (Turkey)
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  • Vasif Hasirci,

    1. METU, BIOMAT Department of Biological Sciences Biotechnology Research Unit 06531 Ankara (Turkey)
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  • Günter Reiter,

    1. Albert-Ludwigs-Universität Physikalisches Institut Hermann-Herder-Str. 3 79104 Freiburg (Germany)
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  • Karine Anselme

    Corresponding author
    1. Institut de Science des Matériaux de Mulhouse CNRS LRC 7228 Université de Haute-Alsace 15, rue Jean Starcky, BP 2488 68057 Mulhouse Cedex (France)
    • Institut de Science des Matériaux de Mulhouse CNRS LRC 7228 Université de Haute-Alsace 15, rue Jean Starcky, BP 2488 68057 Mulhouse Cedex (France).
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Abstract

original image

Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.

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