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Advanced Materials

Rapid Fabrication of Bio-inspired 3D Microfluidic Vascular Networks

Authors

  • Jen-Huang Huang,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
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  • Jeongyun Kim,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
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  • Nitin Agrawal,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
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  • Arjun P. Sudarsan,

    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
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  • Joseph E. Maxim,

    1. National Center for Electron Beam Research, Texas A&M University College Station, TX 77845 (USA)
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  • Arul Jayaraman,

    Corresponding author
    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
    2. Department of Biomedical Engineering, Texas A&M University College Station TX 77843 (USA)
    • Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA).
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  • Victor M. Ugaz

    Corresponding author
    1. Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA)
    • Artie McFerrin Department of Chemical Engineering, Texas A&M University College Station, TX 77843 (USA).
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Abstract

A new method to embed branched 3D microvascular fluidic networks inside plastic substrates by harnessing electrostatic discharge phenomena is introduced. This nearly instantaneous process reproducibly generates highly branched tree-like microchannel architectures that bear remarkable similarity to naturally occurring vasculature. This method can be applied to a variety of polymers, and may help enable production of organ-sized tissue scaffolds containing embedded vasculature.

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