Advanced Materials

Free-Standing Biodegradable Poly(lactic acid) Nanosheet for Sealing Operations in Surgery

Authors

  • Yosuke Okamura,

    1. Department of Life Science and Medical Bioscience Graduate School of Advanced Science and Engineering Waseda University, TWIns Shinjuku-ku, Tokyo, 162-8480 (Japan)
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  • Koki Kabata,

    1. Department of Life Science and Medical Bioscience Graduate School of Advanced Science and Engineering Waseda University, TWIns Shinjuku-ku, Tokyo, 162-8480 (Japan)
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  • Manabu Kinoshita,

    1. Department of Immunology and Microbiology National Defense Medical College Tokorozawa, Saitama, 359-8513 (Japan)
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  • Daizoh Saitoh,

    1. Division of Traumatology National Defense Medical College Tokorozawa, Saitama, 359-8513 (Japan)
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  • Shinji Takeoka

    Corresponding author
    1. Department of Life Science and Medical Bioscience Graduate School of Advanced Science and Engineering Waseda University, TWIns Shinjuku-ku, Tokyo, 162-8480 (Japan)
    • Department of Life Science and Medical Bioscience Graduate School of Advanced Science and Engineering Waseda University, TWIns Shinjuku-ku, Tokyo, 162-8480 (Japan).
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Abstract

A free-standing biodegradable nanosheet composed of poly(L-lactic acid) (PLLA) was shown to have excellent sealing efficacy for a gastric incision as a novel wound dressing material that did not require adhesive agents, and the PLLA nanosheet-induced wound repair showed neither scars nor tissue adhesion. This material may, therefore, be an ideal alternative to conventional tissue repairing procedures using suture/ligation in surgery.

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