The Influence of α-Tricalcium Phosphate Nanoparticles and Microparticles on the Degradation of Poly(D,L-lactide-co-glycolide)

Authors

  • Zhijie Yang,

    Corresponding author
    1. Department of Materials Science and Metallurgy University of Cambridge Pembroke Street, Cambridge, CB2 3QZ, (UK)
    • Department of Materials Science and Metallurgy University of Cambridge Pembroke Street, Cambridge, CB2 3QZ, (UK).
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  • Serena M. Best,

    1. Department of Materials Science and Metallurgy University of Cambridge Pembroke Street, Cambridge, CB2 3QZ, (UK)
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  • Ruth E. Cameron

    1. Department of Materials Science and Metallurgy University of Cambridge Pembroke Street, Cambridge, CB2 3QZ, (UK)
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Abstract

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The in vitro degradation behavior of a series of resorbable, bioactive nano- and microcomposites designed for orthopaedic application is explored. Nanoparticles of α-tricalcium phosphate are significantly more effective than the equivalent microparticles in reducing heterogeneity of the poly(D,L-lactide-co-glycolide) degradation. More uniform degradation, reduced acid release, and less swelling of polymer were observed.

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