A Conducting-Polymer Platform with Biodegradable Fibers for Stimulation and Guidance of Axonal Growth

Authors

  • Anita F. Quigley,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
    2. Centre for Clinical Neuroscience and Neurology Research Department of Medicine, St. Vincent's Hospital 41 Victoria Pde Fitzroy, VIC 3065 (Australia)
    3. Bionic Ear Institute 384-388 Albert St East Melbourne, VIC 3002 (Australia)
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  • Joselito M. Razal,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
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  • Brianna C. Thompson,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
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  • Simon E. Moulton,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
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  • Magdalena Kita,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
    2. Centre for Clinical Neuroscience and Neurology Research Department of Medicine, St. Vincent's Hospital 41 Victoria Pde Fitzroy, VIC 3065 (Australia)
    3. Bionic Ear Institute 384-388 Albert St East Melbourne, VIC 3002 (Australia)
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  • Elizabeth L. Kennedy,

    1. Bionic Ear Institute 384-388 Albert St East Melbourne, VIC 3002 (Australia)
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  • Graeme M. Clark,

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
    2. Bionic Ear Institute 384-388 Albert St East Melbourne, VIC 3002 (Australia)
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  • Gordon G. Wallace,

    Corresponding author
    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
    • ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia).
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  • Robert M. I. Kapsa

    1. ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute University of Wollongong Northfields Avenue Wollongong, NSW 2522 (Australia)
    2. Centre for Clinical Neuroscience and Neurology Research Department of Medicine, St. Vincent's Hospital 41 Victoria Pde Fitzroy, VIC 3065 (Australia)
    3. Bionic Ear Institute 384-388 Albert St East Melbourne, VIC 3002 (Australia)
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Abstract

original image

A biosynthetic platform composed of a conducting polypyrrole sheet embedded with unidirectional biodegradable polymer fibers is described (see image; scale bar = 50 µm). Such hybrid systems can promote rapid directional nerve growth for neuro-regenerative scaffolds and act as interfaces between the electronic circuitry of medical bionic devices and the nervous system.

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