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Active Control of Epithelial Cell-Density Gradients Grown Along the Channel of an Organic Electrochemical Transistor

Authors

  • Maria H. Bolin,

    1. Organic Electronics Department of Science and Technology Linköping University 601 74 Norrköping (Sweden)
    2. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
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  • Karl Svennersten,

    1. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
    2. Department of Neuroscience Karolinska Institutet 171 77 Stockholm (Sweden)
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  • David Nilsson,

    1. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
    2. Acreo AB Box 787 601 17 Norrköping (Sweden)
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  • Anurak Sawatdee,

    1. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
    2. Acreo AB Box 787 601 17 Norrköping (Sweden)
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  • Edwin W. H. Jager,

    1. Organic Electronics Department of Science and Technology Linköping University 601 74 Norrköping (Sweden)
    2. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
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  • Agneta Richter-Dahlfors,

    1. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
    2. Department of Neuroscience Karolinska Institutet 171 77 Stockholm (Sweden)
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  • Magnus Berggren

    Corresponding author
    1. Organic Electronics Department of Science and Technology Linköping University 601 74 Norrköping (Sweden)
    2. Strategic Research Center for Organic Bioelectronics Linköping University 581 83 Linköping (Sweden)
    • Organic Electronics Department of Science and Technology Linköping University 601 74 Norrköping (Sweden).
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Abstract

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Complex patterning of the extracellular matrix, cells, and tissues under in situ electronic control is the aim of the technique presented here. The distribution of epithelial cells along the channel of an organic electrochemical transistor is shown to be actively controlled by the gate and drain voltages, as electrochemical gradients are formed along the transistor channel when the device is biased..

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