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Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy

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Abstract

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End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective (see image).

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