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Communication

Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels

  1. Karin S. Straley2,
  2. Sarah C. Heilshorn1,*

Article first published online: 3 AUG 2009

DOI: 10.1002/adma.200901865

Issue

Advanced Materials

Advanced Materials

Volume 21, Issue 41, pages 4148–4152, November 6, 2009

Additional Information

How to Cite

Straley, K. S. and Heilshorn, S. C. (2009), Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels. Adv. Mater., 21: 4148–4152. doi: 10.1002/adma.200901865

Author Information

  1. 1

    Materials Science and Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA)

  2. 2

    Chemical Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA)

*Materials Science and Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA).

Publication History

  1. Issue published online: 26 OCT 2009
  2. Article first published online: 3 AUG 2009
  3. Manuscript Received: 3 JUN 2009

Funded by

  • National Academies Keck Futures Initiative
  • John and Ulla deLarios Scholar Fund
  • Hellman Faculty Scholar Fund

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Keywords:

  • degradation;
  • delivery;
  • enzymes;
  • hydrogels;
  • patterning
Thumbnail image of graphical abstract

Dynamic, 3D hydrogel patterns emerge over time in response to cell-secreted enzymes (see image). Composite hydrogels fabricated from engineered proteins exhibit customized half-lives ranging across two orders of magnitude due to slight changes in the primary amino acid sequence. The evolution of internal 3D void structures within these polymeric materials is used to release multiple payload molecules with distinct spatial and temporal delivery profiles.

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