Advanced Materials

Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels

Authors

  • Karin S. Straley,

    1. Chemical Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA)
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  • Sarah C. Heilshorn

    Corresponding author
    1. Materials Science and Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA)
    • Materials Science and Engineering Department Stanford University 476 Lomita Mall, McCullough Building 246 Stanford, CA 94305–4045 (USA).
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Abstract

Dynamic, 3D hydrogel patterns emerge over time in response to cell-secreted enzymes (see image). Composite hydrogels fabricated from engineered proteins exhibit customized half-lives ranging across two orders of magnitude due to slight changes in the primary amino acid sequence. The evolution of internal 3D void structures within these polymeric materials is used to release multiple payload molecules with distinct spatial and temporal delivery profiles.

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