Cationic Oligofluorene-Substituted Polyhedral Oligomeric Silsesquioxane as Light-Harvesting Unimolecular Nanoparticle for Fluorescence Amplification in Cellular Imaging



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A new bottom-up strategy is used to construct water-soluble organic/inorganic fluorescent unimolecular nanoparticles based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte. Their high quantum yield, good cytocompatibility, and unique whole-cell permeability could serve as a light-harvesting energy donor to amplify the intracellular dye fluorescence for high-quality biological imaging through fluorescence resonance energy transfer (see image).