Communication

Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements

  1. Franziska Klein1,2,
  2. Thomas Striebel3,
  3. Joachim Fischer3,
  4. Zhongxiang Jiang1,2,
  5. Clemens M. Franz2,
  6. Georg von Freymann3,4,
  7. Martin Wegener3,4,
  8. Martin Bastmeyer1,*

Article first published online: 13 JAN 2010

DOI: 10.1002/adma.200902515

Issue

Advanced Materials

Advanced Materials

Volume 22, Issue 8, pages 868–871, February 23, 2010

Additional Information

How to Cite

Klein, F., Striebel, T., Fischer, J., Jiang, Z., Franz, C. M., von Freymann, G., Wegener, M. and Bastmeyer, M. (2010), Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements. Adv. Mater., 22: 868–871. doi: 10.1002/adma.200902515

Author Information

  1. 1

    Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany)

  2. 2

    DFG-Center for Functional Nanostructures (CFN) Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)

  3. 3

    DFG-Center for Functional Nanostructures (CFN) and Institut für Angewandte Physik Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)

  4. 4

    Institut für Nanotechnologie Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft D-76021 Karlsruhe (Germany)

*Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany).

Publication History

  1. Issue published online: 18 FEB 2010
  2. Article first published online: 13 JAN 2010
  3. Manuscript Revised: 8 AUG 2009
  4. Manuscript Received: 27 JUL 2009

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Keywords:

  • bionanotechnology;
  • cardiomyocytes;
  • direct laser writing;
  • tissue scaffolds
Thumbnail image of graphical abstract

Elastic 3D scaffolds (see figure) are fabricated into a biocompatible photoresist using direct laser writing. These scaffolds can be rhythmically deformed by single beating cardiomyocytes and calibration with atomic force microscopy indicates that cellular forces down to 10–20 nN are detectable with the setup.

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