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Collagen Biomineralization In Vivo by Sustained Release of Inorganic Phosphate Ions

Authors

  • Pamela Habibovic,

    1. Faculty of Dentistry, McGill University 3640 University Street, Montreal, Quebec H3A 2B2 (Canada)
    2. Department of Tissue Regeneration, University of Twente Enschede (The Netherlands)
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  • David C. Bassett,

    1. Faculty of Dentistry, McGill University 3640 University Street, Montreal, Quebec H3A 2B2 (Canada)
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  • Charles J. Doillon,

    1. Department of Surgery, Université Laval Oncology and Molecular Endocrinology Research Centre CHUL Research Centre Quebec City, Quebec (Canada)
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  • Catherine Gerard,

    1. Department of Surgery, Université Laval Oncology and Molecular Endocrinology Research Centre CHUL Research Centre Quebec City, Quebec (Canada)
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  • Marc D. McKee,

    1. Faculty of Dentistry, McGill University 3640 University Street, Montreal, Quebec H3A 2B2 (Canada)
    2. Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, Quebec (Canada)
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  • Jake E. Barralet

    Corresponding author
    1. Faculty of Dentistry, McGill University 3640 University Street, Montreal, Quebec H3A 2B2 (Canada)
    • Faculty of Dentistry, McGill University 3640 University Street, Montreal, Quebec H3A 2B2 (Canada).
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Abstract

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A new strategy for mineralized tissue formation in vivo is presented based on localized sustained delivery of inorganic orthophosphate (Pi) sufficient to supersaturate tissue surrounding an implant and induce mineralization of collagen. After 15 days implantation mineral formation around the implants was detected. Histology and electron microscopy show two populations of apatite; inter-fibrillar microcrystals and nanocrystals associated with collagen.

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