Communication

Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery

  1. Ji-Ho Park1,
  2. Geoffrey von Maltzahn2,
  3. Luvena L. Ong3,
  4. Andrea Centrone3,
  5. T. Alan Hatton3,
  6. Erkki Ruoslahti4,
  7. Sangeeta N. Bhatia2,
  8. Michael J. Sailor1,*

Article first published online: 25 NOV 2009

DOI: 10.1002/adma.200902895

Issue

Advanced Materials

Advanced Materials

Volume 22, Issue 8, pages 880–885, February 23, 2010

Additional Information

How to Cite

Park, J.-H., von Maltzahn, G., Ong, L. L., Centrone, A., Hatton, T. A., Ruoslahti, E., Bhatia, S. N. and Sailor, M. J. (2010), Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery. Adv. Mater., 22: 880–885. doi: 10.1002/adma.200902895

Author Information

  1. 1

    Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)

  2. 2

    Howard Hughes Medical Institute and Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  3. 3

    Department of Chemical Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139 (USA)

  4. 4

    Burnham Institute for Medical Research at UCSB University of California, Santa Barbara 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)

*Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093 (USA)

Publication History

  1. Issue published online: 18 FEB 2010
  2. Article first published online: 25 NOV 2009
  3. Manuscript Revised: 12 OCT 2009
  4. Manuscript Received: 23 AUG 2009

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Keywords:

  • Cancer therapy;
  • Gold nanorods;
  • Liposomes;
  • Micelles;
  • Nanotechnology
Thumbnail image of graphical abstract

A cooperative nanosystem consisting of two distinct nanomaterials works in vivo to detect tumor tissues and deliver drugs to the site. Gold nanorods (GNRs) localize to the tumor region, where they report their location and convert near-infrared radiation to thermal energy. Circulating thermally labile therapeutic liposomes respond to the thermal signal, releasing their drug payload selectively in the GNR-populated tumor.

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