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Advanced Materials

Hierachically Nanostructured Mesoporous Spheres of Calcium Silicate Hydrate: Surfactant-Free Sonochemical Synthesis and Drug-Delivery System with Ultrahigh Drug-Loading Capacity

Authors

  • Jin Wu,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 (P. R. China)
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  • Ying-Jie Zhu,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 (P. R. China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 (P. R. China)
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  • Shao-Wen Cao,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 (P. R. China)
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  • Feng Chen

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 (P. R. China)
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Abstract

Ultrahigh drug-loading capacity and the linear relationship between the cumulative amount of released drug and the natural logarithm of release time were discovered for the hierachically nanostructured mesoporous spheres of calcium silicate hydrate (CSH) obtained by a surfactant-free sonochemical method (see figure). During the release of loaded ibuprofen in simulated body fluid, CSH gradually transformed to hydroxyapatite.

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