Engineering a Material Surface for Drug Delivery and Imaging using Layer-by-Layer Assembly of Functionalized Nanoparticles

Authors

  • Thomas Soike,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
    2. Department of Biomedical Engineering Vanderbilt University Nashville, TN 37232 (USA)
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  • Amanda K. Streff,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
    2. Department of Biomedical Engineering Vanderbilt University Nashville, TN 37232 (USA)
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  • Chenxia Guan,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
    2. Department of Biomedical Engineering Vanderbilt University Nashville, TN 37232 (USA)
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  • Ryan Ortega,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
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  • Mohammed Tantawy,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
    2. Department of Radiology, Vanderbilt Institute of Imaging Sciences Nashville, TN 37232 (USA)
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  • Christopher Pino,

    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
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  • V. Prasad Shastri

    Corresponding author
    1. Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany)
    2. Department of Biomedical Engineering Vanderbilt University Nashville, TN 37232 (USA)
    3. Institute for Macromolecular Chemistry and Bioss-Center for Biological Signalling Studies University of Freiburg 79104 Freiburg (Germany)
    • Institute for Macromolecular Chemistry University of Freiburg Stefan-Meier Strasse 31, 79104 Freiburg (Germany).
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Errata

This article is corrected by:

  1. Errata: Engineering a Material Surface for Drug Delivery and Imaging using Layer-by-Layer Assembly of Functionalized Nanoparticles Volume 22, Issue 18, Article first published online: 3 May 2010

Abstract

original image

Layer-by-layer (LBL) assembly of functionalized nanoparticles (FNPs) within a polyelectrolyte network is described (see image). The LBL-NP-assembly-based modification can be used to engineer surfaces with multiple functions such as controlled (multiple-) drug release with distinct release kinetics and enhanced contrast in clinical imaging modalities. This novel surface modification strategy is expected to accelerate the development of bioresponsive coatings for implantable biomedical devices.

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