Advanced Materials

A Biomolecular “Ship-in-a-Bottle”: Continuous RNA Synthesis Within Hollow Polymer Hydrogel Assemblies

Authors

  • Andrew D. Price,

    1. Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia)
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  • Alexander N. Zelikin,

    1. Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia)
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  • Kim L. Wark,

    1. CSIRO, Division of Molecular and Health Technologies Parkville, Victoria 3052 (Australia)
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  • Frank Caruso

    Corresponding author
    1. Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia)
    • Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria 3010 (Australia).
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Abstract

The use of micrometer-sized, monodisperse polymer hydrogel capsules that act as both microreactors and drug carriers for de novo synthesized RNA is demonstrated (see figure). These capsules are expected to have broad impact as biophysical tools for the study of encapsulated RNA and as new biocompatible delivery vehicles for the cellular delivery of RNA therapeutics.

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