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Advanced Materials

Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery

Authors

  • Daniel A. Bernards,

    1. Department of Bioengineering and Therapeutic Sciences and Department of Physiology University of California, San Francisco San Francisco, CA 94158 (USA)
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  • Tejal A. Desai

    Corresponding author
    1. Department of Bioengineering and Therapeutic Sciences and Department of Physiology University of California, San Francisco San Francisco, CA 94158 (USA)
    • Department of Bioengineering and Therapeutic Sciences and Department of Physiology University of California, San Francisco San Francisco, CA 94158 (USA).
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Abstract

A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic biocompatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.

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