Advanced Materials

Chemosensors for Viruses Based on Artificial Immunoglobulin Copies

Authors

  • Romana Schirhagl,

    1. University of Vienna, Department of Analytical Chemistry and Food Chemistry Währinger Straße 38, 1090 Vienna (Austria)
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  • Peter A. Lieberzeit,

    1. University of Vienna, Department of Analytical Chemistry and Food Chemistry Währinger Straße 38, 1090 Vienna (Austria)
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  • Franz L. Dickert

    Corresponding author
    1. University of Vienna, Department of Analytical Chemistry and Food Chemistry Währinger Straße 38, 1090 Vienna (Austria)
    • University of Vienna, Department of Analytical Chemistry and Food Chemistry Währinger Straße 38, 1090 Vienna (Austria).
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  • Dedicated to Prof. J.-M. Lehn on the occasion of his 70th birthday.

Abstract

“Plastic replicas” of natural antibodies are accessible by molecular imprinting procedures. The first step involves the synthesis of molecularly imprinted polymer (MIP) particles templated with human immunoglobulin. They then can be utilized as templates for a stamp-based surface imprinting procedure that results in polymer surface structures exactly mimicking the initial globulin. Compared to their natural counterparts, these artificial antibodies show improved selectivity and sensitivity on quartz crystal microbalance sensors.

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