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Electrical Detection of DNA Hybridization with Single-Base Specificity Using Transistors Based on CVD-Grown Graphene Sheets

Authors

  • Xiaochen Dong,

    1. School of Materials Science and Engineering, Nanyang Technological University Singapore, 639798 (Singapore)
    2. Jiangsu Key Laboratory for Organic Electronics & Information Displays (KLOEID) Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications (NUPT) 9 Wenyuan Road, Nanjing 210046 (P. R. China)
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  • Yumeng Shi,

    1. School of Materials Science and Engineering, Nanyang Technological University Singapore, 639798 (Singapore)
    2. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Wei Huang,

    1. Jiangsu Key Laboratory for Organic Electronics & Information Displays (KLOEID) Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications (NUPT) 9 Wenyuan Road, Nanjing 210046 (P. R. China)
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  • Peng Chen,

    Corresponding author
    1. School of Chemical and Biomedical Engineering, Nanyang Technological University Singapore, 637459 (Singapore)
    • School of Chemical and Biomedical Engineering, Nanyang Technological University Singapore, 637459 (Singapore).
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  • Lain-Jong Li

    Corresponding author
    1. School of Materials Science and Engineering, Nanyang Technological University Singapore, 639798 (Singapore)
    • School of Materials Science and Engineering, Nanyang Technological University Singapore, 639798 (Singapore).
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Abstract

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Large-sized chemical vapor deposited graphene films configured as solution-gated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (Vg,min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect.

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