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Assemblies of Conjugated Polyelectrolytes with Proteins for Controlled Protein Photoinactivation

Authors

  • Xinrui Duan,

    1. Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry, Chinese Academy of Sciences Beijing 100190, P. R. China
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  • Libing Liu,

    1. Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry, Chinese Academy of Sciences Beijing 100190, P. R. China
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  • Xuli Feng,

    1. Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry, Chinese Academy of Sciences Beijing 100190, P. R. China
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  • Shu Wang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry, Chinese Academy of Sciences Beijing 100190, P. R. China
    • Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry, Chinese Academy of Sciences Beijing 100190, P. R. China.
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Abstract

Conjugated polyelectrolytes are used to specifically inactivate proteins under light irradiation through their assemblies with proteins by electrostatic or metal ion-mediated coordination interactions. Upon light irradiation, the polymer produces reactive oxygen species that react with and inactivate adjacent proteins. The present work adds a new dimension to the function of conjugated polymers.

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