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Two-Photon Excited Fluorescence Enhancement for Ultrasensitive DNA Detection on Large-Area Gold Nanopatterns

Authors

  • Jin-Mi Jung,

    1. Department of Chemical and Biomolecular Engineering (BK-21), Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea)
    2. Department of Materials Science and Engineering, Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Hae-Wook Yoo,

    1. Department of Chemical and Biomolecular Engineering (BK-21), Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea)
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  • Francesco Stellacci,

    1. Department of Materials Science and Engineering, Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Hee-Tae Jung

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering (BK-21), Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea)
    • Department of Chemical and Biomolecular Engineering (BK-21), Korea Advanced Institute of Science and Technology Daejeon 305-701 (Korea).
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Abstract

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Ultrasensitive DNA detection using enhanced two-photon excited fluorescence: DNA detection systems formed on a highly regular gold nanopattern over a large area show enhanced sensitivity from high to ultralow concentrations (∼10−11 M, see figure) target molecules. The observed two-photon excited fluorescence on the gold patterned surface is enhanced over two orders of magnitude compared with the molecules on the glass surface.

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