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Keywords:

  • Micellar nanoparticles;
  • Reversible crosslink;
  • Dual sensitivity;
  • Gene delivery
Thumbnail image of graphical abstract

Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual-sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.