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Advanced Materials

Dual-Sensitive Micellar Nanoparticles Regulate DNA Unpacking and Enhance Gene-Delivery Efficiency

Authors

  • Xuan Jiang,

    1. Department of Materials Science and Engineering Johns Hopkins University Baltimore, MD 21218 (USA)
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  • Yiran Zheng,

    1. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore, MD 21218 (USA)
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  • Hunter H. Chen,

    1. Department of Biomedical Engineering Johns Hopkins University, School of Medicine 720 Rutland Avenue, Baltimore, MD 21231 (USA)
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  • Kam W. Leong,

    1. Department of Biomedical Engineering Duke University Durham, North Carolina 27708 (USA)
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  • Tza-Huei Wang,

    1. Department of Biomedical Engineering Johns Hopkins University, School of Medicine 720 Rutland Avenue, Baltimore, MD 21231 (USA)
    2. Department of Mechanical Engineering Johns Hopkins University Baltimore, MD 21218 (USA)
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  • Hai-Quan Mao

    Corresponding author
    1. Department of Materials Science and Engineering and Whitaker Biomedical Engineering Institute Johns Hopkins University 206 Maryland Hall, Baltimore, MD 21218 (USA)
    • Department of Materials Science and Engineering and Whitaker Biomedical Engineering Institute Johns Hopkins University 206 Maryland Hall, Baltimore, MD 21218 (USA).
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Abstract

Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual-sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.

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