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High-Strength Hydrogels with Integrated Functions of H-bonding and Thermoresponsive Surface-Mediated Reverse Transfection and Cell Detachment

Authors

  • Lei Tang,

    1. School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University, Tianjin 300072 (P. R. China)
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  • Wenguang Liu,

    Corresponding author
    1. School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University, Tianjin 300072 (P. R. China)
    • School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University, Tianjin 300072 (P. R. China).
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  • Guipei Liu

    1. School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University, Tianjin 300072 (P. R. China)
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Abstract

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The construction of a high-strength hydrogel with integrated functions by photo-initiated copolymerization of temperature-sensitive and hydrogen-bonding monomers is described. The hydrogen-bonding and thermoresponsive surface of hydrogels offers a multifunctional platform, where reverse gene transfection and gene-modified cell detachment can be achieved for the potential use in the regeneration and replacement of soft tissue.

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