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Exploring Primary Liver Macrophages for Studying Quantum Dot Interactions with Biological Systems

Authors

  • Hans C. Fischer,

    1. Institute of Biomaterials & Biomedical Engineering University of Toronto Wallberg Building, Toronto, ON M5S 3G9 (Canada)
    2. Department of Materials Science and Engineering University of Toronto Rosebrugh Building, Toronto, ON M5S 3G9 (Canada)
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  • Tanya S. Hauck,

    1. Institute of Biomaterials & Biomedical Engineering University of Toronto Wallberg Building, Toronto, ON M5S 3G9 (Canada)
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  • Alejandro Gómez-Aristizábal,

    1. Department of Dentistry University of Toronto 124 Edwards st., Toronto, ON M5G 1G6 (Canada)
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  • Warren C. W. Chan

    Corresponding author
    1. Institute of Biomaterials & Biomedical Engineering University of Toronto Wallberg Building, Toronto, ON M5S 3G9 (Canada)
    2. Department of Materials Science and Engineering University of Toronto Rosebrugh Building, Toronto, ON M5S 3G9 (Canada)
    • Institute of Biomaterials & Biomedical Engineering University of Toronto Wallberg Building, Toronto, ON M5S 3G9 (Canada)
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Abstract

The effect quantum dots have on primary rat macrophages is investigated, and the findings are compared to in vivo data. In vitro uptake kinetics and degradation both reflect in vivo findings; therefore, primary macrophages are shown to be an appropriate system with which to investigate cellular responses to quantum dots and other nanoparticles in order to guide in vivo studies.

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