Mercury Biosensors: Polydiacetylene–Liposome Microarrays for Selective and Sensitive Mercury(II) Detection (Adv. Mater. 36/2009)

Authors

  • Jiseok Lee,

    1. Macromolecular Science and Engineering University of Michigan Ann Arbor, MI 48109 (USA)
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  • Hayeon Jun,

    1. Department of Material Science and Engineering University of Michigan Ann Arbor, MI 48109 (USA)
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  • Jinsang Kim

    Corresponding author
    1. Macromolecular Science and Engineering University of Michigan Ann Arbor, MI 48109 (USA)
    2. Department of Material Science and Engineering University of Michigan Ann Arbor, MI 48109 (USA)
    3. Chemical Engineering University of Michigan Ann Arbor, MI 48109 (USA)
    4. Biomedical Engineering University of Michigan Ann Arbor, MI 48109 (USA)
    • Macromolecular Science and Engineering University of Michigan Ann Arbor, MI 48109 (USA).
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Abstract

original image

Polydiacetylene (PDA) liposome microarrays have been developed for selective and sensitive mercury detection. The sensors, reported on p. 3674 by Jinsang Kim and co-workers, are designed to produce red fluorescence emission upon binding with Hg2+; when the single-stranded DNA aptamers on the microarray selectively wrap around the mercury ions, the resulting complexes repulse each other. The epoxy-based PDA liposome design is an excellent universal platform that can be readily extended to other sensor designs.

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