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Keywords:

  • angiogenesis;
  • capillary morphogenesis;
  • microfluidics
Thumbnail image of graphical abstract

The cover shows confocal images of 3D sprouting into matrix material in microfluidic channels. Roger Kamm and co-workers report on p. 4863 that robust induction of realistic angiogenesis into the 3D matrix material under simultaneous imaging and a stably controlled concentration gradient of chemoattractants can be achieved. The formation of a 3D vascular network is demonstrated to be a direct consequence of surface treatment of the region of the device-containing matrix material.