Microfluidics: Surface-Treatment-Induced Three-Dimensional Capillary Morphogenesis in a Microfluidic Platform (Adv. Mater. 47/2009)

Authors

  • Seok Chung,

    1. School of Mechanical Engineering, Korea University Anam-Dong, Seongbuk-Gu, Seoul 136-713 (Korea)
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  • Ryo Sudo,

    1. Department of System Design Engineering, Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan)
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  • Ioannis K. Zervantonakis,

    1. Department of Mechanical Engineering and Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Tharathorn Rimchala,

    1. Department of Mechanical Engineering and Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
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  • Roger D. Kamm

    Corresponding author
    1. Department of Mechanical Engineering and Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)
    • Department of Mechanical Engineering and Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
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Abstract

original image

The cover shows confocal images of 3D sprouting into matrix material in microfluidic channels. Roger Kamm and co-workers report on p. 4863 that robust induction of realistic angiogenesis into the 3D matrix material under simultaneous imaging and a stably controlled concentration gradient of chemoattractants can be achieved. The formation of a 3D vascular network is demonstrated to be a direct consequence of surface treatment of the region of the device-containing matrix material.

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