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Development of Extracellular Matrices Mimicking Stepwise Adipogenesis of Mesenchymal Stem Cells

Authors

  • Takashi Hoshiba,

    1. Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
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  • Naoki Kawazoe,

    1. Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
    2. International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
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  • Tetsuya Tateishi,

    1. Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
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  • Guoping Chen

    Corresponding author
    1. Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
    2. International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
    • Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan).
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Abstract

A novel type of extracellular matrices, stepwise adipogenesis-mimicking matrices, was developed from cultured mesenchymal stem cells controlled at different stages of adipogenesis. The matrices derived from stem cells, and the cells controlled at early and late stages of adipogenesis showed different effects on stem cell differentiation.

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