Large Laterally Ordered Nanochannel Arrays from DNA Combing and Imprinting

Authors

  • Jingjiao Guan,

    Corresponding author
    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
    • Current Address: Department of Chemical and Biomedical Engineering FAMU-FSU College of Engineering Center for Materials Research and Technology Integrative NanoScience Institute The Florida State University (USA)
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  • Pouyan E. Boukany,

    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
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  • Orin Hemminger,

    1. Department of Chemical and Biomolecular Engineering, The Ohio State University (USA)
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  • Nan-Rong Chiou,

    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
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  • Weibin Zha,

    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
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  • Megan Cavanaugh,

    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
    2. Department of Chemical and Biomolecular Engineering, The Ohio State University (USA)
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  • L. James Lee

    Corresponding author
    1. Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA)
    2. Department of Chemical and Biomolecular Engineering, The Ohio State University (USA)
    • Nanoscale Science and Engineering Center for Affordable, Nanoengineering of Polymeric Biomedical Devices, The Ohio State University (USA).
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Abstract

original image

We employed patterned surfaces to guide DNA combing in a de-wetting process to form laterally ordered DNA nanostrands. A simple resin imprinting method then converted this structure into nanochannels micro- or nanowell arrays.

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