Get access
Advanced Materials

Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles

Authors

  • Rui Hao,

    1. Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (P. R. China)
    Search for more papers by this author
  • Ruijun Xing,

    1. Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (P. R. China)
    Search for more papers by this author
  • Zhichuan Xu,

    1. Department of Chemistry, Brown University, Providence, RI 02912 (USA)
    Current affiliation:
    1. Current address: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)
    Search for more papers by this author
  • Yanglong Hou,

    Corresponding author
    1. Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (P. R. China)
    • Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871 (P. R. China)
    Search for more papers by this author
  • Song Gao,

    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P. R. China)
    Search for more papers by this author
  • Shouheng Sun

    Corresponding author
    1. Department of Chemistry, Brown University, Providence, RI 02912 (USA)
    • Department of Chemistry, Brown University, Providence, RI 02912 (USA).
    Search for more papers by this author

Abstract

Synthesis of multifunctional magnetic nanoparticles (MFMNPs) is one of the most active research areas in advanced materials. MFMNPs that have magnetic properties and other functionalities have been demonstrated to show great promise as multimodality imaging probes. Their multifunctional surfaces also allow rational conjugations of biological and drug molecules, making it possible to achieve target-specific diagnostics and therapeutics. This review first outlines the synthesis of MNPs of metal oxides and alloys and then focuses on recent developments in the fabrication of MFMNPs of core/shell, dumbbell, and composite hybrid type. It also summarizes the general strategies applied for NP surface functionalization. The review further highlights some exciting examples of these MFMNPs for multimodality imaging and for target-specific drug/gene delivery applications.

Get access to the full text of this article

Ancillary