Communication

Acetal-Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non-Phagocytic Cells

  1. Joel A. Cohen†,
  2. Tristan T. Beaudette,
  3. Jessica L. Cohen,
  4. Kyle E. Broaders,
  5. Eric M. Bachelder‡,
  6. Jean M. J. Fréchet*

Article first published online: 4 JUN 2010

DOI: 10.1002/adma.201000307

Issue

Advanced Materials

Advanced Materials

Volume 22, Issue 32, pages 3593–3597, August 24, 2010

Additional Information

How to Cite

Cohen, J. A., Beaudette, T. T., Cohen, J. L., Broaders, K. E., Bachelder, E. M. and Fréchet, J. M. J. (2010), Acetal-Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non-Phagocytic Cells. Adv. Mater., 22: 3593–3597. doi: 10.1002/adma.201000307

Author Information

  1. College of Chemistry, University of California, Berkeley, CA 94720-1460 (USA)

  1. †

    Present address: Liquidia Technologies, Inc., Research Triangle Park, NC 27709 (USA)

  2. ‡

    Present address: College of Pharmacy, Division of Pharmaceutics, The Ohio State University, Columbus, OH 43210 (USA)

*College of Chemistry, University of California, Berkeley, CA 94720-1460 (USA).

Publication History

  1. Issue published online: 16 AUG 2010
  2. Article first published online: 4 JUN 2010
  3. Manuscript Received: 26 JAN 2010

Funded by

  • National Institutes of Health. Grant Number: PEN Grant 1 U01 HL080729-01 and R01 EB005824

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Keywords:

  • gene delivery;
  • microparticles;
  • biodegradable;
  • acid-sensitive;
  • cell-penetrating peptide
Thumbnail image of graphical abstract

A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and non-phagocytic cells with minimal toxicity.

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