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Advanced Materials

Specific Protein Detection Using Thermally Reduced Graphene Oxide Sheet Decorated with Gold Nanoparticle-Antibody Conjugates

Authors

  • Shun Mao,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA)
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  • Ganhua Lu,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA)
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  • Kehan Yu,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA)
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  • Zheng Bo,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA)
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  • Junhong Chen

    Corresponding author
    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA)
    2. College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, and The Institute for Advanced Materials and Nano Biomedicine, Tongji University, 1239 Siping Road, Shanghai, 200092 (P. R. China)
    • Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211 (USA).
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Abstract

A highly sensitive and selectivefield-effect transistor biosensor using thermally reduced graphene oxide (TRGO) sheet decorated with gold nanoparticle-antibody conjugates is demonstrated. Probe antibody (anti-Immunoglobulin G) is labeled on the surface of the TRGO sheet through gold nanoparticles and electrical detection of the protein binding (Immunoglobulin G and anti-Immunoglobulin G) is accomplished by FET and dc measurements.

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