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In Situ, Label-Free DNA Detection Using Organic Transistor Sensors

Authors

  • Hadayat Ullah Khan,

    1. Max-Planck-Institute for Polymer Research, Material Science Group, Ackermannweg-10, D-55128 Mainz (Germany)
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  • Mark E. Roberts,

    1. Department of Chemical Engineering, Stanford University, 381 North South Mall, Stanford, CA 94305
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  • Olasupo Johnson,

    1. Department of Chemical Engineering, Stanford University, 381 North South Mall, Stanford, CA 94305
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  • Renate Förch,

    1. Max-Planck-Institute for Polymer Research, Material Science Group, Ackermannweg-10, D-55128 Mainz (Germany)
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  • Wolfgang Knoll,

    Corresponding author
    1. Max-Planck-Institute for Polymer Research, Material Science Group, Ackermannweg-10, D-55128 Mainz (Germany)
    2. Austrian Institute of Technology (AIT) GmbH, Donau-City-Str. 1, 1220 Vienna (Austria)
    • Max-Planck-Institute for Polymer Research, Material Science Group, Ackermannweg-10, D-55128 Mainz (Germany)
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  • Zhenan Bao

    Corresponding author
    1. Department of Chemical Engineering, Stanford University, 381 North South Mall, Stanford, CA 94305
    • Department of Chemical Engineering, Stanford University, 381 North South Mall, Stanford, CA 94305.
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Abstract

Organic thin-film transistors modified with 15-base PNA strands are used for the selective detection of target DNA sequences. These simple devices provide a low-cost, label-free and in situ detection platform with excellent discrimination between single and double base mismatches in the target DNA sequence. The electronic detection signal is corroborated with conventional optical methods, displaying similar hybridization parameters.

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