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Dynamically Crosslinked Gold Nanoparticle – Hyaluronan Hydrogels

Authors

  • Aleksander Skardal,

    1. Department of Bioengineering, Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA)
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  • Jianxing Zhang,

    1. Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA)
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  • Lindsi McCoard,

    1. Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA)
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  • Siam Oottamasathien,

    1. Department of Surgery, Division of Pediatric Urology, Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA)
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  • Glenn D. Prestwich

    Corresponding author
    1. Departments of Medicinal Chemistry and Bioengineering, Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA)
    • Departments of Medicinal Chemistry and Bioengineering, Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 (USA).
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Abstract

original image

Bioprinting consists of automated deposition of cells and biomaterials to mimic the architecture of a tissue. Gold nanoparticles act as dynamic, multivalent crosslinkers for thiol-modified hyaluronic acid and gelatin. The resulting synthetic extracellular matrix can be bioprinted into tubular constructs that support cell proliferation and matrix remodeling. The figure shows a view of a tissue construct (containing a fluorescent dye) in the x-y plane, and the inset shows the print head used.

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