Conjugated Oligoelectrolyte Harnessed Polyhedral Oligomeric Silsesquioxane as Light-Up Hybrid Nanodot for Two-Photon Fluorescence Imaging of Cellular Nucleus

Authors

  • Kan-Yi Pu,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576 (Singapore) Fax: (+65) 6779 — 1936
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  • Kai Li,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576 (Singapore) Fax: (+65) 6779 — 1936
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  • Xinhai Zhang,

    1. Institute of Materials Research and Engineering, National University of Singapore, 3 Research Link, Singapore 117602 (Singapore)
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  • Bin Liu

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576 (Singapore) Fax: (+65) 6779 — 1936
    • Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576 (Singapore) Fax: (+65) 6779 — 1936.
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Abstract

original image

A water-soluble organic/inorganic hybrid nanodot based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte is designed and synthesized for two-photon fluorescence imaging of cellular nucleus, which takes advantage of its small size (∼3.3 nm) that imparts nucleus permeability and substantial DNA-enhanced two-photon excited fluorescence that allows illuminating the nucleus with a high contrast.

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