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Reprogramming Directional Cell Motility by Tuning Micropattern Features and Cellular Signals

Authors

  • Keiichiro Kushiro,

    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91106 (USA)
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  • Stephanie Chang,

    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91106 (USA)
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  • Anand R. Asthagiri

    Corresponding author
    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91106 (USA)
    • Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91106 (USA).
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Abstract

Simple geometrical constraints of micropatterned substrates can be used to manipulate the direction and directional persistence of motile cells (scale bar: 20 μm). Modulation of the directional bias is demonstrated by altering pattern parameters and signal pathways.

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