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Advanced Materials

Biointerface by Cell Growth on Layered Graphene–Artificial Peroxidase–Protein Nanostructure for In Situ Quantitative Molecular Detection

Authors

  • Chun Xian Guo,

    1. Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore)
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  • Xin Ting Zheng,

    1. Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore)
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  • Zhi Song Lu,

    1. Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore)
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  • Xiong Wen Lou,

    1. Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore)
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  • Chang Ming Li

    Corresponding author
    1. Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore)
    • Center for Advanced Bionanosystems, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457 (Singapore).
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Abstract

A smart multifunctional biointerface with dimensional compatibility and good electrical conductivity is constructed by growing human breast adenocarcinoma cells on layered graphene–artificial peroxidase–extracellular matrix protein and further used to in situ selectively and quantatively detect reactive oxygen species, for the first time discovering that the number of extracellular released hydrogen peroxide molecules is around 1011 per cell.

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