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Advanced Materials

Temperature as a Single On-Off Parameter Controlling Nanoparticles Growing, Stabilization and Fast Disentanglement

Authors

  • Paula M. López-Pérez,

    1. 3B’s Research Group – Biomaterials, Biodegradables, and Biomimetics, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, (Portugal), IBB – Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga (Portugal)
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  • Ricardo M. P. da Silva,

    Corresponding author
    1. 3B’s Research Group – Biomaterials, Biodegradables, and Biomimetics, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, (Portugal), IBB – Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga (Portugal)
    • 3B’s Research Group – Biomaterials, Biodegradables, and Biomimetics, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, (Portugal), IBB – Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga (Portugal)
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  • Iva Pashkuleva,

    1. 3B’s Research Group – Biomaterials, Biodegradables, and Biomimetics, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, (Portugal), IBB – Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga (Portugal)
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  • Julio San Román,

    Corresponding author
    1. Institute of Polymer Science and Technology, CSIC., C/Juan de la Cierva, 3, 28006-Madrid (Spain), CIBER-BBN (Spain)
    • Institute of Polymer Science and Technology, CSIC., C/Juan de la Cierva, 3, 28006-Madrid (Spain), CIBER-BBN (Spain).
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  • Rui L Reis

    1. 3B’s Research Group – Biomaterials, Biodegradables, and Biomimetics, University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, (Portugal), IBB – Institute for Biotechnology and Bioengineering, PT Government Associated Laboratory, Braga (Portugal)
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Abstract

Thermoresponsive nanoparticles are synthesized from ionic random terpolymer precursors. A distinct temperature-dependent aggregation-redissolution behavior is observed within a subtle balance between polymer ionic charge and hydrophobic content, which is used for colloidal synthesis of nanoparticles in aqueous medium and without surfactants. The solution thermal history provides a robust mean to customize the size of nanoparticles that can be disentangled on command.

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