Advanced Materials

Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies

Authors

  • Yifu Ding,

    Corresponding author
    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
    2. Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO 80309, USA
    • Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO 80309, USA.
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  • Jirun Sun,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
    Current affiliation:
    1. Present address: American Dental Association Foundation, Paffenbarger Research Center, 100 Bureau Dr. Gaithersburg, MD 20899-8546, USA
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  • Hyun Wook Ro,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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  • Zhen Wang,

    1. Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, CO 80309, USA
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  • Jing Zhou,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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  • Nancy J. Lin,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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  • Marcus T. Cicerone,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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  • Christopher L. Soles,

    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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  • Sheng Lin-Gibson

    Corresponding author
    1. Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
    • Polymers Division, National Institute of Standards and Technology, 100 Bureau Dr. Gaithersburg, MD 20899, USA
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Abstract

The initial stages of cell alignment in response to surface topography can be largely described in terms of the work of adhesion encountered by a classical liquid droplet during spreading on a rough surface. This is manifested through a striking correlation between degree of cell alignment and anisotropic wetting of water droplets on the same topographical surfaces.

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