Communication

Batch Fabrication of High-Performance Planar Patch-Clamp Devices in Quartz

  1. John M. Nagarah2,
  2. Eunsu Paek3,
  3. Yi Luo4,
  4. Pin Wang5,
  5. Gyeong S. Hwang3,
  6. James R. Heath1,*

Article first published online: 9 SEP 2010

DOI: 10.1002/adma.201001793

Issue

Advanced Materials

Advanced Materials

Volume 22, Issue 41, pages 4622–4627, November 2, 2010

Additional Information

How to Cite

Nagarah, J. M., Paek, E., Luo, Y., Wang, P., Hwang, G. S. and Heath, J. R. (2010), Batch Fabrication of High-Performance Planar Patch-Clamp Devices in Quartz. Adv. Mater., 22: 4622–4627. doi: 10.1002/adma.201001793

Author Information

  1. 1

    Division of Chemistry & Chemical Engineering, Kavli Nanoscience Institute, California Institute of Technology, Pasadena, CA 91125 (USA)

  2. 2

    Broad Fellows Program, Division of Biology, California Institute of Technology, Pasadena, CA 91125 (USA)

  3. 3

    Cockrell School of Engineering, University of Texas, Austin, TX 78712 (USA)

  4. 4

    College of Engineering, Carnegie Mellon University, Pittsburgh, PA 15213 (USA)

  5. 5

    Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 (USA)

*Division of Chemistry & Chemical Engineering, Kavli Nanoscience Institute, California Institute of Technology, Pasadena, CA 91125 (USA).

Publication History

  1. Issue published online: 22 OCT 2010
  2. Article first published online: 9 SEP 2010
  3. Manuscript Received: 14 MAY 2010

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Keywords:

  • planar patch-clamp;
  • gigaohm seals;
  • metal masks;
  • reactive ion etching;
  • high aspect ratio pore
Thumbnail image of graphical abstract

The success of the patch-clamp technique has driven an effort to create wafer-based patch-clamp platforms. We develop a lithographic/electrochemical processing scheme that generates ultrasmooth, high aspect ratio pores in quartz. These devices achieve gigaohm seals in nearly 80% of trials, with the majority exhibiting seal resistances from 20-80 GΩ, competing with pipette-based patch-clamp measurements.

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