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Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications

Authors

  • Monty Liong,

    1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA)
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  • Huilin Shao,

    1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA)
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  • Jered B. Haun,

    1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA)
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  • Hakho Lee,

    Corresponding author
    1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA)
    • Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA)
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  • Ralph Weissleder

    Corresponding author
    1. Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115 (USA)
    • Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115 (USA).
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Abstract

Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non-cross-linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer-coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro.

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